| task | ours | baseline | margin |
|---|
| model | EH18 Designer |
| parameters | 85,172,000 |
| screening › paste-up floor | 0.626 |
| screening › designs | 0.677 |
| screening › real precursors ceiling | 0.827 |
| screening › random floor | 0.202 |
| screening › neuripp › paste-up floor | 0.714 |
| screening › neuripp › designs | 0.742 |
| screening › neuripp › real precursors ceiling | 0.947 |
| screening › neuripp › random floor | 0.224 |
| screening › baseline beforehand | 0.652 |
| screening › n written | 5,400 |
| screening › n through the screening | 3,455 |
| screening › n kept | 600 |
| novelty, strict › median after aligning | 0.43 |
| novelty, strict › highest | 0.554 |
| novelty, strict › above the threshold | 0 |
| novelty, strict › n | 600 |
| novelty, strict › ceiling, real precursors › median | 0.45 |
| novelty, strict › ceiling, real precursors › highest | 1 |
| novelty, strict › ceiling, real precursors › above the threshold | 44 |
| novelty, strict › floor, shuffled › median | 0.407 |
| novelty, strict › floor, shuffled › highest | 0.581 |
| novelty, strict › floor, shuffled › above the threshold | 0 |
| novelty, strict › withdrawn › median after aligning | 0.366 |
| novelty, strict › withdrawn › highest | 0.507 |
| bigger is not better › 85M | 0.552 |
| bigger is not better › 393M overrun | 0.545 |
| bigger is not better › 393M last stap | 0.5 |
| bigger is not better › difference point | -0.7 |
| precursor rules › lanthipeptide_factor | 123.2 |
| precursor rules › lasso_factor | 32.5 |
| precursor rules › signal share, lanthipeptide | 0.992 |
| precursor rules › signal share, lasso | 0.969 |
| neuripp is strong with one blind spot › neuripp_top1 | 0.773 |
| neuripp is strong with one blind spot › neuripp_top5 | 0.907 |
| neuripp is strong with one blind spot › bgc1_top1 | 0.021 |
| neuripp is strong with one blind spot › floor, chance top-1 | 0.013 |
| neuripp is strong with one blind spot › n clusters | 97 |
| neuripp is strong with one blind spot › missed precursors | 192 |
| neuripp is strong with one blind spot › of proven | 645 |
| neuripp is strong with one blind spot › median neuripp at missed | 0.8046 |
| neuripp is strong with one blind spot › median neuripp at chosen | 1 |
| what it cannot do › tested | none of the 978 designed candidates was tested in a lab. |
| position requirements › lasso_macrolactam › requirement | G or C at core position 1, D or E at position 7, 8 or 9 |
| position requirements › lasso_macrolactam › characterised lassos | 0.6 |
| position requirements › lasso_macrolactam › n calibration | 15 |
| position requirements › lasso_macrolactam › ours, found | 0.432 |
| position requirements › lasso_macrolactam › ours, designed | 0.307 |
| position requirements › lanthipeptide tail cysteine › requirement | a cysteine in the last 7 residues of the core |
| position requirements › lanthipeptide tail cysteine › calibration | 1 |
| position requirements › lanthipeptide tail cysteine › n calibration | 22 |
| position requirements › lanthipeptide tail cysteine › calibration floor | 0.336 |
| position requirements › lanthipeptide tail cysteine › ours, found | 0.722 |
| position requirements › lanthipeptide tail cysteine › ours, designed | 0.794 |
| novelty gate in the screening › literal copies caught | 60/60 |
| novelty gate in the screening › copy with one insertion caught | 0/60 |
| novelty gate in the screening › our 600 designs, spread | 16,2% tot 16,9%, drempel 80% |
| lanthipeptide › own orfs | 1,301,240 |
| lanthipeptide › own hits | 712 |
| lanthipeptide › foreign orfs | 450,339 |
| lanthipeptide › foreign hits | 2 |
| lanthipeptide › own clusters | 10,825 |
| lanthipeptide › foreign clusters | 6,360 |
| lanthipeptide › own share | 0.0005 |
| lanthipeptide › foreign share | 0 |
| lanthipeptide › factor | 123.2061 |
| lanthipeptide › expected chance hits | 5.7789 |
| lanthipeptide › signal share | 0.9919 |
| lasso › own orfs | 304,462 |
| lasso › own hits | 41 |
| lasso › foreign orfs | 1,447,117 |
| lasso › foreign hits | 6 |
| lasso › own clusters | 1,928 |
| lasso › foreign clusters | 15,257 |
| lasso › own share | 0.0001 |
| lasso › foreign share | 0 |
| lasso › factor | 32.479 |
| lasso › expected chance hits | 1.2624 |
| lasso › signal share | 0.9692 |
| measured with | no model |
| orfs › LAP/thiopeptide | 907,901 |
| orfs › cyanobactin | 643,868 |
| orfs › lanthipeptide | 1,371,366 |
| orfs › lasso | 352,370 |
| clusters › LAP/thiopeptide | 6,615 |
| clusters › cyanobactin | 1,999 |
| clusters › lanthipeptide | 10,825 |
| clusters › lasso | 1,928 |
| hits › LAP/thiopeptide › A F[DN]L[DN] | 353 |
| hits › LAP/thiopeptide › B FDLD | 285 |
| hits › LAP/thiopeptide › C FDLD+1C+1ST | 169 |
| hits › LAP/thiopeptide › D FDLD+2C+2ST | 135 |
| hits › LAP/thiopeptide › E FDLD+3C | 104 |
| hits › LAP/thiopeptide › F FDLD..C within 30 | 129 |
| hits › LAP/thiopeptide › G D and F together | 116 |
| hits › cyanobactin › A F[DN]L[DN] | 277 |
| hits › cyanobactin › B FDLD | 227 |
| hits › cyanobactin › C FDLD+1C+1ST | 129 |
| hits › cyanobactin › D FDLD+2C+2ST | 101 |
| hits › cyanobactin › E FDLD+3C | 79 |
| hits › cyanobactin › F FDLD..C within 30 | 103 |
| hits › cyanobactin › G D and F together | 91 |
| hits › lanthipeptide › A F[DN]L[DN] | 1,213 |
| hits › lanthipeptide › B FDLD | 1,040 |
| hits › lanthipeptide › C FDLD+1C+1ST | 879 |
| hits › lanthipeptide › D FDLD+2C+2ST | 824 |
| hits › lanthipeptide › E FDLD+3C | 731 |
| hits › lanthipeptide › F FDLD..C within 30 | 825 |
| hits › lanthipeptide › G D and F together | 795 |
| hits › lasso › A F[DN]L[DN] | 141 |
| hits › lasso › B FDLD | 116 |
| hits › lasso › C FDLD+1C+1ST | 82 |
| hits › lasso › D FDLD+2C+2ST | 73 |
| hits › lasso › E FDLD+3C | 58 |
| hits › lasso › F FDLD..C within 30 | 73 |
| hits › lasso › G D and F together | 66 |
| clusters hit › LAP/thiopeptide › A F[DN]L[DN] | 296 |
| clusters hit › LAP/thiopeptide › B FDLD | 243 |
| clusters hit › LAP/thiopeptide › C FDLD+1C+1ST | 142 |
| clusters hit › LAP/thiopeptide › D FDLD+2C+2ST | 113 |
| clusters hit › LAP/thiopeptide › E FDLD+3C | 87 |
| clusters hit › LAP/thiopeptide › F FDLD..C within 30 | 106 |
| clusters hit › LAP/thiopeptide › G D and F together | 95 |
| clusters hit › cyanobactin › A F[DN]L[DN] | 223 |
| clusters hit › cyanobactin › B FDLD | 188 |
| clusters hit › cyanobactin › C FDLD+1C+1ST | 104 |
| clusters hit › cyanobactin › D FDLD+2C+2ST | 81 |
| clusters hit › cyanobactin › E FDLD+3C | 64 |
| clusters hit › cyanobactin › F FDLD..C within 30 | 82 |
| clusters hit › cyanobactin › G D and F together | 72 |
| clusters hit › lanthipeptide › A F[DN]L[DN] | 1,054 |
| clusters hit › lanthipeptide › B FDLD | 913 |
| clusters hit › lanthipeptide › C FDLD+1C+1ST | 772 |
| clusters hit › lanthipeptide › D FDLD+2C+2ST | 725 |
| clusters hit › lanthipeptide › E FDLD+3C | 644 |
| clusters hit › lanthipeptide › F FDLD..C within 30 | 725 |
| clusters hit › lanthipeptide › G D and F together | 699 |
| clusters hit › lasso › A F[DN]L[DN] | 115 |
| clusters hit › lasso › B FDLD | 97 |
| clusters hit › lasso › C FDLD+1C+1ST | 68 |
| clusters hit › lasso › D FDLD+2C+2ST | 61 |
| clusters hit › lasso › E FDLD+3C | 50 |
| clusters hit › lasso › F FDLD..C within 30 | 61 |
| clusters hit › lasso › G D and F together | 55 |
| clusters chosen › LAP/thiopeptide › A F[DN]L[DN] | 53 |
| clusters chosen › LAP/thiopeptide › B FDLD | 42 |
| clusters chosen › LAP/thiopeptide › C FDLD+1C+1ST | 41 |
| clusters chosen › LAP/thiopeptide › D FDLD+2C+2ST | 41 |
| clusters chosen › LAP/thiopeptide › E FDLD+3C | 37 |
| clusters chosen › LAP/thiopeptide › F FDLD..C within 30 | 37 |
| clusters chosen › LAP/thiopeptide › G D and F together | 36 |
| clusters chosen › cyanobactin › A F[DN]L[DN] | 24 |
| clusters chosen › cyanobactin › B FDLD | 19 |
| clusters chosen › cyanobactin › C FDLD+1C+1ST | 19 |
| clusters chosen › cyanobactin › D FDLD+2C+2ST | 19 |
| clusters chosen › cyanobactin › E FDLD+3C | 17 |
| clusters chosen › cyanobactin › F FDLD..C within 30 | 19 |
| clusters chosen › cyanobactin › G D and F together | 19 |
| clusters chosen › lanthipeptide › A F[DN]L[DN] | 538 |
| clusters chosen › lanthipeptide › B FDLD | 478 |
| clusters chosen › lanthipeptide › C FDLD+1C+1ST | 472 |
| clusters chosen › lanthipeptide › D FDLD+2C+2ST | 469 |
| clusters chosen › lanthipeptide › E FDLD+3C | 440 |
| clusters chosen › lanthipeptide › F FDLD..C within 30 | 457 |
| clusters chosen › lanthipeptide › G D and F together | 455 |
| clusters chosen › lasso › A F[DN]L[DN] | 18 |
| clusters chosen › lasso › B FDLD | 17 |
| clusters chosen › lasso › C FDLD+1C+1ST | 16 |
| clusters chosen › lasso › D FDLD+2C+2ST | 16 |
| clusters chosen › lasso › E FDLD+3C | 15 |
| clusters chosen › lasso › F FDLD..C within 30 | 15 |
| clusters chosen › lasso › G D and F together | 15 |
| measured with | no model |
| orfs › LAP/thiopeptide | 907,901 |
| orfs › cyanobactin | 643,868 |
| orfs › lanthipeptide | 1,371,366 |
| orfs › lasso | 352,370 |
| clusters › LAP/thiopeptide | 6,615 |
| clusters › cyanobactin | 1,999 |
| clusters › lanthipeptide | 10,825 |
| clusters › lasso | 1,928 |
| hits › LAP/thiopeptide › A knot | 128,480 |
| hits › LAP/thiopeptide › B knot+EVG | 4,218 |
| hits › LAP/thiopeptide › C knot+AELT | 244 |
| hits › LAP/thiopeptide › D knot+EVG+AELT | 10 |
| hits › LAP/thiopeptide › E knot+long motif | 1 |
| hits › cyanobactin › A knot | 90,702 |
| hits › cyanobactin › B knot+EVG | 2,906 |
| hits › cyanobactin › C knot+AELT | 184 |
| hits › cyanobactin › D knot+EVG+AELT | 5 |
| hits › cyanobactin › E knot+long motif | 1 |
| hits › lanthipeptide › A knot | 196,451 |
| hits › lanthipeptide › B knot+EVG | 6,139 |
| hits › lanthipeptide › C knot+AELT | 416 |
| hits › lanthipeptide › D knot+EVG+AELT | 17 |
| hits › lanthipeptide › E knot+long motif | 1 |
| hits › lasso › A knot | 51,007 |
| hits › lasso › B knot+EVG | 1,702 |
| hits › lasso › C knot+AELT | 180 |
| hits › lasso › D knot+EVG+AELT | 53 |
| hits › lasso › E knot+long motif | 3 |
| clusters hit › LAP/thiopeptide › A knot | 6,515 |
| clusters hit › LAP/thiopeptide › B knot+EVG | 2,228 |
| clusters hit › LAP/thiopeptide › C knot+AELT | 219 |
| clusters hit › LAP/thiopeptide › D knot+EVG+AELT | 10 |
| clusters hit › LAP/thiopeptide › E knot+long motif | 1 |
| clusters hit › cyanobactin › A knot | 1,999 |
| clusters hit › cyanobactin › B knot+EVG | 1,133 |
| clusters hit › cyanobactin › C knot+AELT | 159 |
| clusters hit › cyanobactin › D knot+EVG+AELT | 5 |
| clusters hit › cyanobactin › E knot+long motif | 1 |
| clusters hit › lanthipeptide › A knot | 10,711 |
| clusters hit › lanthipeptide › B knot+EVG | 3,456 |
| clusters hit › lanthipeptide › C knot+AELT | 385 |
| clusters hit › lanthipeptide › D knot+EVG+AELT | 16 |
| clusters hit › lanthipeptide › E knot+long motif | 1 |
| clusters hit › lasso › A knot | 1,923 |
| clusters hit › lasso › B knot+EVG | 820 |
| clusters hit › lasso › C knot+AELT | 162 |
| clusters hit › lasso › D knot+EVG+AELT | 52 |
| clusters hit › lasso › E knot+long motif | 3 |
| clusters chosen › LAP/thiopeptide › A knot | 1,384 |
| clusters chosen › LAP/thiopeptide › B knot+EVG | 93 |
| clusters chosen › LAP/thiopeptide › C knot+AELT | 15 |
| clusters chosen › LAP/thiopeptide › D knot+EVG+AELT | 6 |
| clusters chosen › LAP/thiopeptide › E knot+long motif | 1 |
| clusters chosen › cyanobactin › A knot | 434 |
| clusters chosen › cyanobactin › B knot+EVG | 30 |
| clusters chosen › cyanobactin › C knot+AELT | 7 |
| clusters chosen › cyanobactin › D knot+EVG+AELT | 3 |
| clusters chosen › cyanobactin › E knot+long motif | 1 |
| clusters chosen › lanthipeptide › A knot | 2,373 |
| clusters chosen › lanthipeptide › B knot+EVG | 134 |
| clusters chosen › lanthipeptide › C knot+AELT | 24 |
| clusters chosen › lanthipeptide › D knot+EVG+AELT | 11 |
| clusters chosen › lanthipeptide › E knot+long motif | 1 |
| clusters chosen › lasso › A knot | 911 |
| clusters chosen › lasso › B knot+EVG | 132 |
| clusters chosen › lasso › C knot+AELT | 57 |
| clusters chosen › lasso › D knot+EVG+AELT | 38 |
| clusters chosen › lasso › E knot+long motif | 3 |
| measured with | no model |
| clusters | 1,604 |
| families | 1,534 |
| train | 1,284 |
| test | 320 |
| measurement › largest class guessing › correct | 0.2281 |
| measurement › largest class guessing › interval | 0.1812 – 0.2751 |
| measurement › 4-mers + linear layer › correct | 0.4594 |
| measurement › 4-mers + linear layer › interval | 0.4093 – 0.5125 |
| measurement › EH14 X, 512-base windows › correct | 0.5031 |
| measurement › EH14 X, 512-base windows › interval | 0.4531 – 0.5563 |
| measurement › BGC-1, 512-base windows › correct | 0.6937 |
| measurement › BGC-1, 512-base windows › interval | 0.6468 – 0.7438 |
| measurement › BGC-1, 2048-base windows › correct | 0.7406 |
| measurement › BGC-1, 2048-base windows › interval | 0.6906 – 0.7875 |
| measured with | EH14 X, 6.7 M (previous version) – BGC-1 |
| size | 7,171,796,732 |
| rules | 12,824,758 |
| on | 02-10-2026 13:18 |
| measured with | no model |
| bgc-1 › gpu hours | 180.85 |
| bgc-1 › gpu minutes | 10,851 |
| bgc-1 › cpu hours | 0 |
| eh14x › gpu hours | 0 |
| eh14x › gpu minutes | 0 |
| eh14x › cpu hours | 22.2 |
| eh14x › cpu minutes | 1,331 |
| chemistry › residue pairs › T-C | 10 |
| chemistry › residue pairs › S-C | 8 |
| chemistry › residue pairs › C-T | 2 |
| chemistry › residue pairs › other | 5 |
| chemistry › distance › median | 5 |
| chemistry › distance › mean | 6.3 |
| chemistry › distance › within 2 to 7 | 20/25 |
| result › 1 ring › ceiling | 29/30 |
| result › 1 ring › floor, average protein | 4/30 |
| result › 1 ring › floor, same composition | 25/30 |
| result › 2 rings › ceiling | 20/30 |
| result › 2 rings › floor, average protein | 0/30 |
| result › 2 rings › floor, same composition | 14/30 |
| result › 3 rings › ceiling | 9/30 |
| result › 3 rings › floor, average protein | 0/30 |
| result › 3 rings › floor, same composition | 8/30 |
| composition › real core › C | 0.088 |
| composition › real core › S | 0.105 |
| composition › real core › T | 0.152 |
| composition › average protein › C | 0.011 |
| composition › average protein › S | 0.058 |
| composition › average protein › T | 0.054 |
| applied › precursors | 1,390 |
| applied › clusters | 1,143 |
| applied › with 1 ring › precursors | 779 |
| applied › with 1 ring › clusters | 528 |
| applied › with 2 rings › precursors | 432 |
| applied › with 2 rings › clusters | 334 |
| applied › with 3 rings › precursors | 218 |
| applied › with 3 rings › clusters | 183 |
| own orfs | 855,345 |
| foreign orfs | 896,234 |
| own clusters | 6,615 |
| foreign clusters | 10,570 |
| variants › B CTTC › own hits | 292 |
| variants › B CTTC › foreign hits | 238 |
| variants › B CTTC › own share | 0.0003 |
| variants › B CTTC › foreign share | 0.0003 |
| variants › B CTTC › factor | 1.2855 |
| variants › B CTTC › clusters | 275 |
| variants › B CTTC › signal share | 0.2221 |
| variants › C C[ST][ST]C › own hits | 1,498 |
| variants › C C[ST][ST]C › foreign hits | 1,518 |
| variants › C C[ST][ST]C › own share | 0.0018 |
| variants › C C[ST][ST]C › foreign share | 0.0017 |
| variants › C C[ST][ST]C › factor | 1.034 |
| variants › C C[ST][ST]C › clusters | 1,072 |
| variants › C C[ST][ST]C › signal share | 0.0329 |
| variants › D C..C.C.C › own hits | 148 |
| variants › D C..C.C.C › foreign hits | 58 |
| variants › D C..C.C.C › own share | 0.0002 |
| variants › D C..C.C.C › foreign share | 0.0001 |
| variants › D C..C.C.C › factor | 2.6737 |
| variants › D C..C.C.C › clusters | 122 |
| variants › D C..C.C.C › signal share | 0.626 |
| variants › E 4C and 4ST › own hits | 28,973 |
| variants › E 4C and 4ST › foreign hits | 29,655 |
| variants › E 4C and 4ST › own share | 0.0339 |
| variants › E 4C and 4ST › foreign share | 0.0331 |
| variants › E 4C and 4ST › factor | 1.0237 |
| variants › E 4C and 4ST › clusters | 5,382 |
| variants › E 4C and 4ST › signal share | 0.0232 |
| variants › A long pattern › own hits | 12 |
| variants › A long pattern › foreign hits | 1 |
| variants › A long pattern › own share | 0 |
| variants › A long pattern › foreign share | 0 |
| variants › A long pattern › factor | 12.5736 |
| variants › A long pattern › clusters | 12 |
| variants › A long pattern › signal share | 0.9205 |
| measured with | no model |